S. V. Khabarov

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One of the main problems in tumor chemotherapy is the appearance of resistance of the tumors to drugs. The causes of resistance are as a rule multiple in character. For instance, resistance of tumors to bifunctional alkylating agents is connected with a disturbance of transport of the substances into the cell [9], with intensification of DNA repair(More)
The aim of this work is to estimate the shower leakage from the CMS Endcap Hadron calorimeter (HE) due to electromagnetic secondaries and punch-through in the region of the ME1/1 Forward Muon Station. Two configurations are considered: with and without the CMS Endcap Electromagnetic calorimeter (EE). The experimental data has been taken during the combined(More)
A synthesized analog of myelopeptide HP-2-->M[symbol: see text]-2 (Leu-Val-Val-Tyr-Pro-Trp) caused a significant (60-80%) and prolonged inhibition of s.c. grafted tumors P388, Ca-755, B-16 and sarcoma 180 in isogenic mice but did not affect the growth of tumor B-16 in nude mice. Nor did it influence proliferative activity or viability of cultured human(More)
The sites of specific binding of 3H-L-dihydroalprenolol (3H-DHA) were identified on the surface of ascites sarcoma 37 cells, using competitive displacement and binding of the beta-adrenergic antagonists, 3H-DHA and L-propranolol. These binding sites possessed the properties of beta-adrenergic receptors coupled with adenylate cyclase. Analysis of 3H-DHA(More)
Beta-adrenoceptors have been discovered on the surface of cells of leukaemia L1210 and its variant resistant to sarcolysine (D, L-melphalan). One type of functionally active receptors with dissociation constant Kd for L-[3H] dihydroalprenolol about 0.02 nM and 360 receptors per cell have been revealed in leukaemia L1210 cells. In the resistant cells two(More)
Myelopeptide-2 (MP-2) is classified with bone-marrow immunoregulatory mediators, which were discovered by Russian scientists [4]. After isolation of MP-2 from the supernatant of a bovine bone-marrow cell culture and determination of its structure (Leu–Val–Val– Tyr–Pro–Trp), MP-2 was synthesized [3]. The studies of the MP-2 biological activity showed that it(More)
The effect of cisplatin and the new drug cycloplatam (amine (cyclopentylamine)-S-(-)-malatoplatinum (II)) on protein kinase C (PKC) activity and Ca(2+)-dependent binding of PKC to T lymphocytes membranes was studied in vivo and in vitro. At first, the effect of the drugs on PKC activity of intact and activated lymphocytes was studied in vivo. In 48 hours(More)
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