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OBJECTIVE To determine the incidence of vaginal cuff dehiscence after minimally invasive hysterectomy, we reported our series of total laparoscopic hysterectomies with transvaginal colporraphy. STUDY DESIGN We then conducted a systematic search of PubMed to retrieve published series of laparoscopic and robotic hysterectomies, in which different techniques(More)
BACKGROUND Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. METHODS Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. RESULTS Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+(More)
BACKGROUND Type I and II endometrial cancer are biologically and clinically distinct, with type II cancers having a high frequency of p53 mutations and an association with chromosomal instability. This raises the hypothesis that one-carbon nutrients (folate, methionine, and the enzymic cofactors vitamins B2, B6, and B12), which mediate chromosomal stability(More)
BACKGROUND Pelvic lymph nodes are the most common site of extrauterine tumor spread in early-stage endometrial cancer, but the clinical impact of lymphadenectomy has not been addressed in randomized studies. We conducted a randomized clinical trial to determine whether the addition of pelvic systematic lymphadenectomy to standard hysterectomy with bilateral(More)
BACKGROUND There is as yet limited evidence about fertility-sparing surgery for early ovarian cancer (EOC) carried out laparoscopically. We sought to analyze recurrence patterns and fertility outcome in a cohort of ovarian cancer patients who underwent fertility-saving laparoscopic surgical staging. METHODS We conducted a retrospective analysis of(More)
BACKGROUND AND PURPOSE Segmental callosal agenesis is characterized by the absence of the intermediate callosal portion. We aimed to evaluate the structural connectivity of segmental callosal agenesis by using constrained spherical deconvolution tractography and connectome analysis. MATERIALS AND METHODS We reviewed the clinical-radiologic features of 8(More)
AIM To assess long-term subjective, objective, and urodynamic outcomes of retropubic mid-urethral slings at 13-year follow-up. METHODS This was a prospective observational study. Consecutive women with proven urodynamic stress incontinence were treated with standard retropubic tension free vaginal tape (TVT). Patients with mixed incontinence and/or(More)
We read with much interest the article by Fanning et al 1 entitled " Effects of Electrosurgery and Vaginal Closure Technique on Postoperative Vaginal Cuff Dehiscence, " regarding the rate of vaginal cuff dehiscence after laparo-scopic hysterectomy. The issue is extremely important because vaginal cuff breakdown can cause severe post-operative morbidity and(More)
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