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OBJECTIVE To present our experience with the Gamma-knife in treating large uveal melanomas with stereotactic radiosurgery. DESIGN Prospective, noncomparative, interventional case series. PARTICIPANTS Fifty-eight patients with unilateral uveal melanomas were treated from 1996 through 1999 with stereotactic radiosurgery using the Gamma-knife. From these(More)
A rangable stimulation tool based on the sonar microstereometric system has been developed for the intraoperative identification of the central motor strip. The elicited motor evoked potentials (MEPs) were recorded with surface electrodes and displayed together with the corresponding stereometric coordinates of the stimulation site. MEP data were overlaid(More)
In cases of large volume and highly prominent melanomas of the uvea, it is rare for conventional methods of radiation therapy to enable salvage of the globe or even residual functionality of the affected eye. Complications due to the massive amount of accumulated necrotic tissue often necessitate subsequent enucleation of the blinded eye. Tumor-destroying,(More)
BACKGROUND We report our experience with stereotactic radiosurgery using the Gamma-knife in large uveal melanoma unsuitable for brachytherapy (Ru106). PATIENTS AND METHODS We treated 35 patients (16 male, 19 female; age: median 59 years (95% Confidence interval (CI): 31-84 years; 18 right eyes, 17 left eyes). 7 tumors were located juxtapapillary, 16(More)
BACKGROUND The aim of this non-comparative, consecutive case series is to evaluate the short-term results after endoresection of large uveal melanomas in combination with pretreatment with stereotactic gamma knife radiosurgery. METHODS Between March 2000 and November 2002, forty-six patients with large uveal melanomas underwent stereotactic radiosurgery(More)
BACKGROUND We report the results over 3 years with stereotactic radiosurgery using the Gamma Knife for large and unsuitably located uveal melanomas. PATIENTS AND METHODS A total of 100 patients (51 male, 49 female) have been treated since 1997 following a standardised treatment protocol (outpatient single-shot treatment, maximum dose 50 Gy, tumour margin(More)
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