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PURPOSE OF REVIEW Older obese persons with decreased muscle mass or strength are at special risk for adverse outcomes. We discuss potential pathways to muscle impairment in obese individuals and the consequences that joint obesity and muscle impairment may have on health and disability. Tantamount to this discussion is whether low muscle mass or, rather,(More)
OBJECTIVES To examine long-term changes in handgrip strength and the factors predicting handgrip strength decline. DESIGN Longitudinal cohort study with 22 years of follow-up. SETTING Population-based Mini-Finland Health Examination Survey in Finland. PARTICIPANTS Nine hundred sixty-three men and women aged 30 to 73 at baseline. MEASUREMENTS(More)
BACKGROUND An excessive amount of adipose tissue may contribute to sarcopenia and may be one mechanism underlying accelerated loss of muscle mass and strength with aging. We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was(More)
Obesity in older adults is a growing public health problem. Excess weight causes biomechanical burden to lower extremity joints and contribute to joint pathology. The aim of this study was to identify specific characteristics of gait associated with body mass index (BMI). Preferred and maximum speed walking and related gait characteristics were examined in(More)
OBJECTIVE To examine the independent and combined associations of obesity and muscle strength with mortality in adult men and women. DESIGN Follow-up study with 33 years of mortality follow-up. SUBJECTS A total of 3594 men and women aged 50-91 years at baseline with 3043 deaths during the follow-up. MEASUREMENT Body mass index (BMI) and handgrip(More)
BACKGROUND Stress has damaging effects on individual's health. However, information about the long-term consequences of mental stress is scarce. METHODS This 28-year prospective cohort study examined on the associations between midlife stress and old age disability among 2,994 Finnish municipal professionals aged 44-58 years at baseline. Self-reported(More)
Diabetes may impact gait mechanics before onset of frank neuropathies and other associated threats to mobility. This study aims to characterize gait pattern alterations of type 2 diabetic adults without peripheral neuropathy during walking at maximum speed (fast-walking) as well as at self-selected speed (usual-walking). One-hundred and eighty-six(More)
Data on how body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are associated with body fat in the oldest-old people are scarce. The purpose of this study was to examine if BMI, WC or WHR are associated with leptin, a biological surrogate measure of body fat in 90-year-old people. The data comes from the Vitality 90+ Study, a(More)
BACKGROUND Long-term predictors of geriatric syndrome of frailty are unclear. Several obesity-related conditions are associated with frailty. This study examines the predictive role of midlife overweight and obesity on development of frailty more than 22 years of follow-up. METHODS Data are from 1,119 men and women aged 30 or older without frailty at(More)
OBJECTIVES To study the association between different obesity indicators and walking limitation and to examine the role of C-reactive protein (CRP) and handgrip strength in that association. DESIGN A cross-sectional, population-based study. SETTING The Health 2000 Survey with a representative sample of the Finnish population. PARTICIPANTS Subjects(More)