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Modern therapy for pediatric acute lymphoblastic leukemia (ALL) is based on the principle of risk stratification. One of the most important laboratory features used to accurately risk stratify patients is the presence of specific chromosomal translocation within the leukemic blasts. In this paper, we describe a multiplex reverse transcriptase-polymerase(More)
The t(12;21)(p13;q22) is a cryptic abnormality observed in 25% of children with B-lineage acute lymphoblastic leukemia (ALL), associated with a favorable prognosis. To determine whether specific cytogenetic abnormalities accompany the t(12;21), we analyzed the cytogenetic profiles of blast cells from 169 ALL cases positive for the t(12;21), previously(More)
9577 Background: 11q23/MLL abnormalities are generally associated with unfavorable prognosis in acute myeloid leukemia (AML). More than 50 partners have been described for MLL, and 35 of these partners have been cloned and analyzed at the molecular level to date. The functional role of each specific fusion transcript on the progression and outcome of(More)
As hospitals face severe financial constraints, the need to review programs to ensure cost-effectiveness is critical. Waste management practices have come under scrutiny because inappropriate waste disposal is very costly. The Wellesley Hospital in Toronto, Ontario conducted a waste audit in July 1993 and found that 18.5% of waste was being disposed of as(More)
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