S. Sekar

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RATIONALE The majority of psychoactive compounds, including antidepressants in clinical practice, were discovered largely by serendipity. The underlying neuropharmacological mechanisms of action of these compounds leading to resolution of depressive symptomatology are targets of the current research. Pharmacological magnetic resonance imaging (phMRI), a(More)
RATIONALE One of the key targets of psychopharmacology research is to determine the potential sites of action of antidepressants in order to characterise their underlying mechanism of action. OBJECTIVE Using blood oxygenation level-dependent (BOLD) pharmacological magnetic resonance imaging (phMRI), the neuroanatomical target-sites of reboxetine (a(More)
An effective NMDA antagonist imaging model may find key utility in advancing schizophrenia drug discovery research. We investigated effects of subchronic treatment with the NMDA antagonist memantine by using behavioural observation and multimodal MRI. Pharmacological MRI (phMRI) was used to map the neuroanatomical binding sites of memantine after acute and(More)
In this paper, a new method of analysis for second order initial value problems using the RK-Butcher algorithms is presented. To illustrate the effectiveness of the RK-Butcher algorithms, seven problems of different kinds have been considered and the solutions were obtained using the RK method based on Arithmetic mean (RKAM), Centroidal mean (RKCeM) and the(More)
  • Sekar S, Willems R, Veraart J, Van Audekerke, J Couto, Giugliano M +14 others
  • 2014
Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI. Psychopharmacology (Berl). Subchronic memantine effects revealed by multimodal MRI Sekar S et al. ABSTRACT: Background: An effective NMDA antagonist imaging-model may find key utility in advancing