S. Sadekar

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Antibody drug conjugates (ADCs) are a multi-component modality comprising of an antibody targeting a cell-specific antigen, a potent drug/payload, and a linker that can be processed within cellular compartments to release payload upon internalization. Numerous ADCs are being evaluated in both research and clinical settings within the academic and(More)
The purpose of this study was to model data from a head to head comparison of the in vivo fate of hyperbranched PAMAM dendrimers with linear HPMA copolymers in order to understand the influence of molecular weight (MW), hydrodynamic size (R h), and polymer architecture on biodistribution in tumor-bearing mice using compartmental pharmacokinetic analysis.(More)
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