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Plastic (araldite) needles were implanted in the cerebral cortex in order to evaluate changes produced by an indwelling and relatively inert foreign body. The implants were removed together with surrounding cortex after 4-723 days and the implant-CNS boundary analyzed by light and electron microscopy. Three border conditions were observed at the surface of(More)
Histopathological changes of the cerebral cortex in response to small, penetrating metal and non-metal implants were analyzed by means of light and electron microscopy. The needle-shaped implants were left in place during all stages of histological preparation and embedded in plastic together with the cortex. Changes of the brain-implant boundary were(More)
The distribution of dopamine D-1 receptors has been determined in human prefrontal cortex (Brodmann's area 9) by an in vitro light microscopic autoradiographic method. Dopamine D-1 receptors were localized by using [3H]SCH 23390 as a ligand. Our results indicated that [3H]SCH 23390 binding to slide-mounted tissue sections of human brain is specific,(More)
Two sets of electrode arrays made of either 25- or 50-microns-diameter Teflon-insulated platinum-iridium wire and Teflon have been developed for chronic intracortical electrical stimulation. Cortical histological studies were performed following acute and chronic implantation in cats. While some neural damage resulted from the implantations of either array(More)
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