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BACKGROUND The shortage of mental health care in rural China might be tackled by community care. This study tests the hypothesis that family intervention increases patients' treatment compliance, which is crucial in community care. METHOD A cohort of psychiatric patients were randomly selected to a controlled trial for four months. Compliance rates,(More)
We investigated mechanisms involved in the modulation of long-term potentiation by low concentrations of N-methyl-D-aspartate in the CA1 region of rat hippocampal slices. When applied for 5 min prior to and during tetanic stimulation, 1 microM N-methyl-D-aspartate inhibited long-term potentiation induction. Studies examining paired-pulse facilitation of(More)
AIM To study the effects of SSF, an effective part isolated from Scutellaria baicalensis George, on memory impairments and the pathological changes of neural and immunological systems in senescent mice induced by chronic galactose. METHODS Senescent performance in mice was induced by consecutive administration of D-galactose (120 mg/kg, ip) for 47 d. The(More)
Medulloblastoma is the most common malignant brain tumor in childhood, and development of targeted therapies is highly desired. Although the molecular mechanisms of malignant transformation are not fully understood, it is known that medulloblastomas may arise from cerebellar granule neuron precursors. The homeodomain transcription factor Barhl1 is known to(More)
Inducing long-term depression (LTD), one type of synaptic plasticity, typically requires electrical stimulation. Using rat hippocampal slices, we show that increasing the Ca(2+) of the extracellular solution to 4 mM and decreasing the Mg(2+) to 0.1 mM induced LTD in the CA1 region in the absence of electrical stimulation. The ionically-induced-LTD occluded(More)
INTRODUCTION Lymphoid enhancer-binding factor-1 (LEF1) is a target gene and central mediator of the Wnt signaling pathway. High LEF1 expression has been reported as a prognostic marker in several types of hematologic malignancies of adult patients. METHODS In this study, LEF1 expression was analyzed by real-time polymerase chain reaction (PCR) in 122(More)
The mechanism of relaxing effects of lidocaine (Lid) on the contraction of isolated rabbit thoracic aortic rings was studied. Verapamil (Ver) was used for comparison. Lid and Ver showed obvious relaxing effect on contraction evoked by high K+ depolarization. In the study of contractions induced by noradrenaline (NA), both Lid and Ver were shown to suppress(More)
Substantial evidence suggests that breast cancer initiation, recurrence and drug resistance is supported by breast cancer stem cells (BCSCs). Recently, we reported a novel role of Aurora kinase A (AURKA) in BCSCs, as a transactivating co-factor in the induction of the c-Myc oncoprotein. However, the mode of action and transcriptional network of nuclear(More)