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The present study concerns the involvement of descending bulbospinal serotonergic pathways in blood pressure regulation in both normotensive and neurogenically hypertensive rats. We found that direct stimulation of serotonergic receptors of the spinal cord induced a depressor response which was prevented by prior catecholaminergic denervation in… (More)
Acute propranolol reduced the synthesis rate of serotonin in several rat brain structures (hypothalamus, midbrain, pons, frontal cortex and medulla oblongata). Both optical isomers of propranolol were tested. From our results it may be concluded that both the beta-blocking property and the local anaesthetic action of the drug could be involved in its… (More)