S. Petruzzi

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Nerve growth factor (NGF) is a polypeptide growth factor which exerts trophic and differentiative effects on specific peripheral and central populations of neurons. Recent data showing that various cellular types of the endocrine and immune systems are able to synthesize and release NGF have suggested that this neurotrophic factor may also play an important(More)
Sulfur dioxide (SO2) is one of the most important pollutants of the western countries, responsible for several cardiopulmonary diseases in humans. SO2 affects both young and adult people, causing low work productivity with social and economical costs extremely high for the communities. To test whether or not SO2 produces changes in social and/or agonistic(More)
The present study evaluated the behavioral repertoire of lactating CD-1 mouse dams when tested in an environment associated with cocaine in the premating period. Virgin females were randomly assigned for conditioning (8-day long schedule with four cocaine or saline injections administered every other day) to three experimental groups: i) Coc-Test females(More)
CD-1 mice were continuously exposed to ozone (O3) from 6 days before the formation of breeding pairs to Day 17 of pregnancy. The concentrations used were 0, 0.2, 0.4, and 0.6 ppm; the lowest-observed-effect levels for eye irritation and respiratory function are in the range of 0.08-0.2 ppm for both humans and animals (47). Ozone failed to produce(More)
The present paper is devoted to second- and higher-tier test methods for the characterization of behavioral changes produced in rodents by exposure to noxious agents during development. The paper analyzes a series of end points that are informative about specific processes and underlying regulatory mechanisms but require greater technical sophistication and(More)
There is evidence that activity at the GABA/benzodiazepine receptor complex in specific brain areas might be enhanced during rodent motherhood. We tested the hypothesis that the manipulation of this neurochemical system by prenatal benzodiazepine exposure affects typical behavioral responses of lactating mouse dams. Outbred CD-1 mouse fetuses were(More)
Outbred CD-1 mice were exposed continuously to ozone (O3, 0.6 ppm) from 6 days prior to the formation of breeding pairs to the time of weaning of the offspring on postnatal day 22 (PND 22) or to PND 26. One half of the mice in each of eight O3 and eight control litters were subjected on PND 24 to a 20-min open-field test after IP treatment by either saline(More)
Exposure to altered gravitational environment, especially during critical ontogenetic phases, may induce persistent nervous system modifications and behavioural anomalies. This study evaluated the effects of hypergravity exposure on the development of the nervous system and assessed the relevance of parity in the mother's responses to altered gravitational(More)
Outbred CD 1 mice were either not exposed (control group) or exposed to ozone (O3) (0.3, 0.6, or 0.9 ppm), during foetal and neonatal life until the time of weaning (postnatal day (PND) 26). On PND 70 the subjects were tested for handedness using a paw preference task assessing both the animals' capability to reach a food pellet in a feeding tube and the(More)