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It is widely accepted that the adult mammalian central nervous system (CNS) is unable to regenerate axons. In addition to physical or molecular barriers presented by glial scarring at the lesion site, it has been suggested that the normal myelinated CNS environment contains potent growth inhibitors or lacks growth-promoting molecules. Here we investigate(More)
To determine critical periods of action, the effects of trophic factors on rat lumbar dorsal root ganglion (DRG) neurons were evaluated during neurogenesis, and after neurogenesis, before and after target contact. Brain-derived neurotrophic factor and neurotrophin-4 increased E12.5 DRG neuronal survival. Leukemia inhibitory factor enhanced neuronal(More)
Neuronal differentiation involves specific molecular and morphological changes in precursors and results in mature, postmitotic neurons. The expression of neuron-specific beta tubulin, as detected by the monoclonal antibody TuJ1, begins during the period of neurogenesis. Indeed, TuJ1 expression precedes that of the 160 kD neurofilament protein in both the(More)
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