S P Hicks

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Normal and abnormal development of movement in the rat were studied by investigating the growth and organization of the motor-sensory cortexcorticospinal tract system (MSC-CST) and the functional and morphologic effects of ablating the MSC or quadrants of it at different ages. Major growth of the MSC outflow, the CST, in the brain stem and rostral cord(More)
Brain sections from patients who had died with senile dementia of the Alzheimer's type (SDAT), Huntington's disease (HD), or no neurologic disease were studied by autoradiography to measure sodium-independent L-[3H]glutamate binding. In brain sections from SDAT patients, glutamate binding was normal in the caudate, putamen, and claustrum but was lower than(More)
Different views of the location and organization of corticospinal (CS) neurons in the rat have resulted from fiber degeneration studies, electro-physiologically derived somatotopic maps, studies of CS axonal branching, and functional alterations af'ter ablation of parts of the motor-sensory cortex. To locate more precisely CS neurons that projected to(More)
Normal Development and Post-Traumatic Plasticity of Corticospinal Neurons in Rats Corticospinal (CS) neurons projecting to the spinal cord in the adult rat, identified by retrograde axonal transport of horseradish peroxidase (HRP), formed a caudal band in areas 3, 4, and 6 and a rostra1 band in area 10, separated by a gap. In the infant the gap was filled(More)
Irradiation of prenatal and infant rats resulted in a spectrum of highly reproducible nervous system malformations associated with locomotor abnormalities difficult to correlate with morphologic findings. Fetal rats exposed to 150 R on the 13th, 14th. or 15th day ofgestation were born with a hopping gait, paired hind and forelimbs moving in unison instead(More)
In studies of cerebral glucose metabolism utilising positron emission tomography (PET) with 18F-fluoro-2-deoxy-D-glucose, patients with the clinical picture of progressive supranuclear palsy (PSP) have shown predominantly frontal glucose hypometabolism. This is presumed to represent deafferentation of cerebral cortical from subcortical structures. In these(More)
From July 1, 1980 to December 2, 1982, all individuals at autopsy at the University of Michigan Medical Center greater than or equal to 65 years of age and selected individuals less than 65 years of age were examined for neuritic plaques and neurofibrillary tangles. Sections of the hippocampal, parahippocampal temporal gyrus, and fusiform gyrus were(More)
Seven affected individuals from three generations in a kindred having over 250 members were identified as having possible, probable, or definite Creutzfeldt-Jakob disease. Spongiform encephalopathy was found at postmortem examination in two cases. Detailed inpatient neurological examinations were performed on four of the subjects, three of whom were first(More)
A recessive mutation which arose in Wistar albino rats was variably expressed in the homozygous state as prenatal stenosis of the aqueduct with resultant hydrocephalus. The condition was often compatible with survival to adulthood and with successful reproduction. Mildly sparse hair was the constant gene marker. Eye defects and sometimes foot deformities(More)
We studied a patient with a vascular malformation within the pons and medulla, affecting the cranial nerve nuclei, ascending and descending pathways, and cerebellar peduncles and adjoining structures. The symptoms had been present for more than 50 years. They were fluctuating in the beginning but later were progressive. The malformation probably had its(More)