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  • Simon Hawley, Mark Davison, +4 authors David Grahame Hardie
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1996 (First Published: 1 November 1996)
  • We have developed a sensitive assay for the AMP-activated protein kinase kinase, the upstream component in the AMP-activated protein kinase cascade. Phosphorylation and activation of the downstreamContinue Reading
  • S P Davies, David Carling, David Grahame Hardie
  • Biology, Medicine
  • European journal of biochemistry
  • 1989 (First Published: 1 December 1989)
  • 1. We have synthesized two peptides, one based on the exact sequence around the unique site (Ser79) for the AMP-activated protein kinase on rat acetyl-CoA carboxylase (SSMS peptide) and another inContinue Reading
  • S P Davies, Nicholas R Helps, Patricia Townsend Wade Cohen, David Grahame Hardie
  • Biology, Medicine
  • FEBS letters
  • 1995 (First Published: 27 December 1995)
  • Human protein phosphatase-2C alpha (PP2C alpha) was purified to homogeneity after expression in Escherichia coli. AMP inhibited the dephosphorylation of AMP-activated protein kinase (AMPK), but notContinue Reading
  • Jason R. B. Dyck, Naomi Kudo, Amy J. Barr, S P Davies, David Grahame Hardie, Gary D Lopaschuk
  • Biology, Medicine
  • European journal of biochemistry
  • 1999 (First Published: 15 May 1999)
  • Acetyl-CoA carboxylase (ACC) is regarded in liver and adipose tissue to be the rate-limiting enzyme for fatty acid biosynthesis; however, in heart tissue it functions as a regulator of fatty acidContinue Reading
  • S P Davies, Simon Hawley, Angela Woods, David Carling, Timothy A. J. Haystead, David Grahame Hardie
  • Biology, Medicine
  • European journal of biochemistry
  • 1994 (First Published: 1 July 1994)
  • The AMP-activated protein kinase has been purified by affinity chromatography on ATP-gamma-Sepharose. A proportion of the activity can be eluted using AMP, while the remainder is eluted using ATP.Continue Reading