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AIM The aim of this study was to validate the computed tomography (CT) features of intra-abdominal hypertension (IAH) by relating them to the clinical measurement of intra-abdominal pressure (IAP) in critically ill surgical patients. MATERIALS AND METHODS The intra-vesical pressure was measured to reflect IAP in 24 critically ill patients. CT examinations(More)
OBJECTIVE Percutaneous transhepatic biliary intervention (PTBI) plays an important role in the management of biliary obstruction, and this may be complicated by acute pancreatitis. The aim of this study was to assess the incidence of acute pancreatitis following PTBI. PATIENTS AND METHODS Patients who underwent PTBI between January 1992 and December 2003(More)
BACKGROUND Moderate to severe psoriasis is associated with increased alcohol intake and excessive mortality from alcohol-related causes. Alcohol biomarkers provide an objective measure of alcohol consumption. Carbohydrate-deficient transferrin (CDT) is the single most sensitive and specific alcohol biomarker. OBJECTIVES To assess alcohol consumption in a(More)
BACKGROUND There are limited data on the use of ustekinumab outside of clinical trials. OBJECTIVES To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland. METHODS A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab. RESULTS(More)
BACKGROUND Dermatological teaching has traditionally stressed that complete skin examination is essential in the assessment of patients with potential skin disease. OBJECTIVES To determine whether complete skin examination results in increased diagnoses of skin malignancies that would not have been discovered otherwise. METHODS New patients (n = 483)(More)
Cutaneous sarcoidosis has multiple presentations, is remarkably resistant to treatment, but rarely results in scarring. A 37-year-old white woman presented with an eruption that had begun on her arms 2 years earlier, and gradually spread to the face and scalp. Apart from its dramatic appearance, the rash was asymptomatic. The patient was taking venlafaxine(More)
AIM To determine the impact on diagnostic and interventional radiology services when imaging patients with severe pancreatitis on intensive therapy (ITU) and high-dependency units (HDU) in a tertiary referral centre. MATERIAL AND METHODS One hundred and sixty-nine patients admitted to ITU/HDU over a 9-year period (1996-2004) with severe acute pancreatitis(More)
Survival from melanoma is influenced by several, well-established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basis for these observations. Preliminary results indicated a(More)
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