S O Lawesson

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The structure of the modified dipeptide Z-Glyt-Gly-OBzl is reported with special emphasis on the linear and angular dimensions of the thiopeptide unit. It is shown that, except for the differences between the carbonyl and the thioacyl bond lengths, there are no significant differences between the oxopeptide and the thiopeptide unit.
In connection with work on 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (I), used for thiation of carbonyl compounds, different kinds of compounds with semipolar bondings have been reacted with I, especially C- and N-nitroso compounds. C-Nitroso compounds give azoxy and azo compounds. N-Nitroso compounds give new phosphorus ring(More)
The reaction between N-nitrosamides and 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (LR) at low temperature (20-50 degrees C) gives the corresponding thioamides as the main products. In the reaction between N-nitroso-2-pyrrolidone and LR, dihydro-2-(3H)-thiophenone (III) is also isolated. Mechanistic considerations for the formation(More)
The in vitro opioid activities of a series of leucine enkephalin analogs containing a thioamide linkage in place of the peptide bond at various positions of the backbone were determined in mu- and delta-receptor-selective bio- and binding-assays. Thioamide substitution in the 1-2 position resulted in an inactive compound, whereas the same modification in(More)
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