S O Cole

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After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals in the 5 mg/kg dose condition(More)
Evidence related to the effects of benzodiazepines on learning and memory is reviewed in the contexts of human verbal learning studies and animal studies using both aversive and non-aversive paradigms. While the impairment of acquisition by benzodiazepines appears to be a robust phenomenon generalizing across species and experimental conditions, the(More)
Use of stimulant drugs in the treatment of hyperkinetic children is reviewed briefly. While drugs appear to be effective in "normalizing" behavior, too little attention has been paid to potential side effects. There is need for a broader program of clinical evaluation, assessing drug effects not only on behavior, but on appetite and the cardiovascular(More)
Chlordiazepoxide (CDP) (5 mg/kg) administered on four of eight sessions significantly impaired the performance of a previously learned, reinforcement-cued discrimination in male Sprague-Dawley rats. On four interspersed vehicle-injection sessions, the performance of subjects demonstrated immediate recovery and was indistinguishable from that of controls (0(More)
The effects of chlordiazepoxide (CDP-0, 5, 10 mg/kg) on feeding, rearing, and ambulatory locomotion of male Holtzman rats were investigated in an open-field arena under 3 different conditions of food deprivation (0, 24, 48 hr). Both CDP and food deprivation enhanced feeding, with their combined effects being essentially additive. Also, CDP significantly(More)
Diazepam (2.0 and 4.0 mg/kg, but not 1.0 mg/kg) administered in eight acquisition sessions significantly impaired the light-cued successive discrimination of male Sprague-Dawley rats. In two postdrug (vehicle) sessions, groups previously treated with the drug demonstrated good recovery in discrimination. An analysis of response components indicated that the(More)
Chlordiazepoxide (10 mg/kg), administered on eight successive acquisition sessions, impaired a light-cued, successive discrimination in male Sprague-Dawley rats by increasing the number of incorrect responses. The benzodiazepine receptor antagonist Ro 15-1788 (5 and 10 mg/kg) reversed the discrimination impairment and reduced the number of incorrect(More)
The effects of d-amphetamine (0.0, 0.5, 1.0. 2.0 mg/kg) on feeding and activity of male Holtzman rats were investigated in 3 different size test arenas. Differences in the size of arenas significantly altered the drug's effect on ambulatory activity, but not on feeding or rearing. Also, differences in the size of arenas significantly altered the(More)