S. Nischal

Learn More
Epigenetic changes play important roles in carcinogenesis and influence initial steps in neoplastic transformation by altering genome stability and regulating gene expression. To characterize epigenomic changes during the transformation of normal plasma cells to myeloma, we modified the HpaII tiny fragment enrichment by ligation-mediated PCR assay to work(More)
Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-amino-glutamyl analogue of thalidomide that lacks the neurologic side effects of sedation and neuropathy and has emerged as a drug with activity(More)
5-hydroxymethylcytosine (5-hmC) is a recently discovered epigenetic modification that is altered in cancers. Genome-wide assays for 5-hmC determination are needed as many of the techniques for 5-methylcytosine (5-mC) determination, including methyl-sensitive restriction digestion and bisulfite sequencing cannot distinguish between 5-mC and 5-hmC.(More)
—We propose a combined uplink/downlink oppor-tunistic scheduling algorithm for infrastructure WLANs. In the presence of both uplink and downlink flows, an infrastructure WLAN suffers from the uplink/downlink unfairness problem which severely decreases the throughput of the access point (AP). We resolve the unfairness by maintaining a separate queue and a(More)
We propose a Cooperative Opportunistic Automatic Repeat ReQuest (CoARQ) scheme to solve the HOL-blocking problem in infrastructure IEEE 802.11 WLANs. HOL blocking occurs when the head-of-the-line packet at the Access Point (AP) queue blocks the transmission of packets to other destinations resulting in severe throughput degradation. When the AP transmits a(More)
Pr ecis: Although most low grade prostate cancers appear to be indolent, this study establishes that a subset can progress to higher grades and may already harbor features that can be used to predict their progression. Pr ecis: Expression of potassium ion channels occurs with some frequency in various human cancers, where they may offer possible therapeutic(More)
  • 1