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Because granulocyte colony-stimulating factor (G-CSF) is known to induce granulopoiesis and activate mature neutrophils, this factor could be important in determining the number and functional activity of neutrophils at sites of lung disease. The purpose of this study was to evaluate the ability of lung immune and inflammatory cells to produce G-CSF, and to(More)
  • P Soler, S Nioche, +6 authors A J Hance
  • Thorax
  • 1987
To examine the possibility that mast cells have a central role in the pathogenesis of hypersensitivity pneumonitis, 20 patients with this disease were studied with the aim of seeking evidence for mast cell degranulation. The number of mast cells recovered by bronchoalveolar lavage from patients with hypersensitivity pneumonitis was more than 1,000 times(More)
To evaluate the production of granulocyte colony-stimulating factor (G-CSF) by human immune and inflammatory cells, an assay specifically measuring G-CSF activity in the presence of other cytokines was developed which was based on the proliferation of 32Dcl cells induced by G-CSF. Successful use of the 32Dcl cells to specifically measure G-CSF activity(More)
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