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Activation of the stress-activated protein kinase (SAPK/JNK) by genotoxic agents is necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation exposure induces translocation of SAPK to mitochondria and association of SAPK with the anti-apoptotic Bcl-x(L) protein. SAPK phosphorylates Bcl-x(L) on threonine 47 (Thr-47) and(More)
Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-xL fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stress. Coimmunoprecipitation studies demonstrate that Bcl-xL(More)
BACKGROUND Quality of life is becoming an important component of overall assessment in health care settings. However, satisfactory instruments are not available for use in India. METHODS Qualitative and quantitative work was conducted at the Delhi centre as a part of the WHOQOL (World Health Organization Quality of Life) project at 15 centres in(More)
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be an important nosocomial pathogen. Various hospital-based studies have described the incidence of MRSA and carriage of this organism in health care workers. Recently, even community acquired S. aureus strains have shown resistance to methicillin. This changing epidemiology prompted us to(More)
Four bacterial strains (I-IV) capable of optimum growth on 0.1% naphthalene, anthracene or a mixture of naphthalene and phenanthrene were isolated from soil near an oil refinery. Two isolates (I and II) were identified as belonging to the genus Micrococcus, while strains III and IV were identified as Pseudomonas and Alcaligenes respectively. All the(More)
Apoptosis has been shown to contribute to loss of cardiomyocytes in cardiomyopathy, progressive decline in left ventricular function, and congestive heart failure. Because the molecular mechanisms involved in apoptosis of cardiocytes are not completely understood, we studied the biochemical and ultrastructural characteristics of upstream regulators of(More)
BACKGROUND It is unclear whether adherence to prescribing standards has been achieved in inflammatory bowel disease (IBD). AIM To determine how prescribing of 5-aminosalicylates (5-ASAs), steroids and thiopurines has changed in response to emerging evidence. METHODS We examined trends in oral and topical therapies in 23 509 incident IBD cases (6997 with(More)