S. N. Bobkova

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Comparative effect of eiconol (resource of omega-3 PUFA) and lipostabil on lipid, biochemical, hemostatic parameters in blood and activity of lipolytic enzymes in thrombocytes and monocytes was studied in 18 clinic patients with ischemic heart disease fed antiatherosclerotic diet during 2 weeks. On basis of these parameters was concluded that eiconol and(More)
73 Atherosclerosis has recently been associated with pathological processes occurring in the vascular endothelium. The efficacy of antiatherosclerotic drugs is consequently determined by their capability of pro tecting the vascular wall [1, 2]. In view of this, trietha nol ammonium salts of aroxiacetic acids with a pro tatrane structure [3] attract(More)
131 The relationship between high molecular weight complexes of aminoacyl tRNA synthetases (ARSs) and their stimulatory effect on protein synthesis has been recently established. Tryptophanyl tRNA syn thetase (TRS) was shown to be activated by hemin [1], phorbol ester [2], and erythropoietin [3]. In this con nection, tris 2 (hydroxyethyl) ammonium 2 meth(More)
137 In recent years, the interest of researchers is drawn to studying the involvement of lysosomal lipolytic enzymes responsible for the degradation of lipid com ponents of lipoproteins (LPs) in atherogenesis. The involvement of these enzymes in the mechanism of disturbance of the metabolism of lipids and lipopro teins in atherosclerosis has been confirmed,(More)
The experiments reported here demonstrated that prophylactic use of trecrezan delayed the development of atherosclerosis in rabbits, with decreases in aortic atherosclerotic plaques and reductions in cholesterol, triacylglycerols, and β-lipoprotein levels in serum, liver, and aortic tissue. Trecrezan accelerated the synthesis of tryptophanyl tRNA(More)
219 It is commonly acknowledged that atherosclerosis is a multifactorial disease with a complex pathogene sis. The development of atherosclerosis is associated with pathological processes in the vascular endothe lium, and the efficacy of antiatherosclerotic drugs is, to some extent, determined by their ability to protect the vascular wall [1]. In this(More)
270 It is known that atherosclerosis is associated with pathological processes in the vascular endothelium. The early stage of atherogenesis includes activation of endothelium, which expresses adhesion molecules for monocytes, neutrophils and white blood cells on its surface and produces chemoattractants that attract monocytes into the intima of blood(More)
It was established that application of the domestic preparation trecrezan for the treatment of experimental atherosclerosis in rabbits led to decreases in the levels of cholesterol and total lipids in platelets (Tc) and monocytes (Mc) of the blood. Results of enzymatic analysis indicated that the development of atherosclerosis was accompanied by increased(More)
211 It is known that lipid metabolism disturbances in the form of atherogenic hypercholesterolemia are accompanied by an increased blood clotting, which justifies the use of drugs with anticoagulant and lipoly tic activity, such as heparin, in these conditions. In turn, coagulation hemostasis and lipid profile are largely determined by enzymatic reactions(More)
In vitro experiments performed on rabbits showed that tris-2-(hydroxyethyl)ammonium orthocresoxyacetate (trecrezan) increases the cytokine activity of total tryptophanyl mRNA synthase (TRSase) via stimulation of the synthesis of a specific mRNA synthase (TRSase). This explains the mechanisms of the hypolipidemic, immunomodulatory, and adaptogenic actions of(More)
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