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Angiotensin I-converting enzyme (ACE) has two homologous active NH2- and COOH-terminal domains and displays activity toward a broad range of substrates. The tetrapeptide N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) has been shown to be hydrolyzed in vitro by ACE and to be a preferential substrate for its NH2-terminal active site. This peptide is a(More)
Sulfated polysaccharides from marine macroalgae have been shown to possess a variety of biological activities against fungi, bacteria, viruses, and protozoa. In this study, the in vitro activity of algal polysaccharides against Leishmania infantum (Kinetoplastida: Trypanosomatidae) was investigated. The polysaccharides were extracted from different(More)
This paper investigates the properties of DNA translocations signals in a stochastic framework. The considered signals are relative to the translocation of single strand DNA through natural nanopores, and are obtained using a planar patch clamp method. The stochastic signal analysis is carried out considering the statistical distribution of DNA(More)
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