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Noise-induced hearing loss (NIHL) is one of the most important occupational health hazards. Millions of people worldwide are exposed daily to harmful levels of noise. NIHL is a complex disease resulting from an interaction between genetic and environmental factors. Although the environmental risk factors have been studied extensively, little is known about(More)
For content based image retrieval using shape descriptors, most approaches so far extract shape information from a seg-mentation of the image. Shape features derived based on a specific segmentation are not suitable for images containing complex structures. Further, static segmentation based approaches are useful only for a small set of queries. In this(More)
R ´ ESUMÉ : We consider two variants of knapsack problems with setups arising as subproblems in a Dantzig-Wolfe decomposition approach to more complex combinatorial optimization problems. In the multiple-class binary knapsack problem with setups, items are partitioned into classes whose use implies a setup cost and associated capacity consumption. Item(More)
the date of receipt and acceptance should be inserted later Abstract. When a column generation approach is applied to decomposable mixed integer programming problems, it is standard to formulate and solve the master problem as a linear program. Seen in the dual space, this results in the algorithm known in the nonlinear programming community as the(More)
In the past decade, significant progress has been achieved in developing generic primal heuristics that made their way into commercial mixed integer programming (MIP) solver. Extensions to the context of a column generation solution approach are not straightforward. The Dantzig-Wolfe decomposition principle can indeed be exploited in greedy, local search,(More)
MOTIVATION We present a pipeline for the pre-processing, quality assessment, read distribution and methylation estimation for methylated DNA immunoprecipitation (MeDIP)-sequence datasets. This is the first MeDIP-seq-specific analytic pipeline that starts at the output of the sequencers. This pipeline will reduce the data analysis load on staff and allows(More)
Archival of images in databases, enabling further study with respect to their contents, is at our focus of attention. The major difficulties are i) the processing of a large number of images, ii) that the steadily growing number of images increase the complexity of the pattern recognition problems to be solved. We propose orientation radiograms, to be used(More)
Waldenstr m's Macroglobulinemia is a rare chronic lymphoproliferative disease. Clinical manifestations include usually weakness, weight loss, lymphadenopathy. Lung, kidney, heart, nervous system or bone may be involved. Cutaneous manifestations are unusual and misunderstood. Two different types of cutaneous lesions are described: non-specific and specific.(More)
We consider an application of the inventory routing problem. A fleet of vehicles is devoted to collecting a single product from geographically dispersed sites. Each site has its own accumulation rate and stock capacity. On each visit, the vehicle empties the stock. At the tactical level, the objective is to minimize the fleet size and an estimate of the(More)