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Cell death was examined by studying the spinal cords of rats subjected to traumatic insults of mild to moderate severity. Within minutes after mild weight drop impact (a 10 gm weight falling 6.25 mm), neurons in the immediate impact area showed a loss of cytoplasmic Nissl substances. Over the next 7 d, this lesion area expanded and cavitated. Terminal(More)
Schwann cells (SCs) have been shown to be a key element in promoting axonal regeneration after being grafted into the central nervous system (CNS). In the present study, SC-supported axonal regrowth was tested in an adult rat spinal cord implantation model. This model is characterized by a right spinal cord hemisection at the eighth thoracic segment,(More)
Raphe-spinal (R-S) neurons were identified in the nucleus raphe magnus (NRM). The conduction velocity of their axons was calculated to be about 15-60 m/sec. The great majority of R-S neurons did not respond clearly to non-noxious stimuli, such as brushing hair or lightly pressing the skin, but they did respond to noxious stimuli (pricking or clamping), with(More)
Neuroprotection following ischaemic stroke is driven by the interplay between regulatory transcription factors and endogenous protective factors. IRF4, a member of the interferon regulatory factor (IRF) family, is implicated in the survival of tumour cells. However, its role in the survival of normal cells including neurons remains elusive. Using genetic(More)
Experiments were performed on male rats. The responses of dorsal horn convergent neurons in spinal cord (T12-L1) to noxious stimulation of hind paw were recorded extracellularly with glass microelectrode. When low intensity (2 V) electroacupuncture (EA) was used, the nociceptive responses of convergent neurons were inhibited by EA at "Zusanli" near noxious(More)
Effects of microinjection of vasoactive intestinal peptide (VIP) into cisterna magna, dorsal vagal complex (dorsal motor nucleus of the vagus, nucleus tractus solitarius and area postrema) and spinal subarachnoid space on gastric acid secretion (GAS) were observed in Ghosh-Schild's rats. The results were as follows: (1) VIP (10 micrograms) injected into the(More)
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