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The retinoid receptors belong to a large superfamily of ligand-inducible transcription factors that include the steroid, vitamin D and thyroid hormone receptors, the peroxisome proliferator-activated receptor, the insect edysteroid receptor, and a number of orphan receptors whose ligands are unknown. All nuclear receptors have several well-characterized(More)
The chimeric receptor, RARα/VDR, contains the DNA-binding domain of the retinoic acid receptor (RARα) and the ligand-binding domain of the vitamin D receptor (VDR). The ligand-binding properties of RARα/VDR are equivalent to that of VDR, with an observed Kd for 1α,25 dihydroxy-vitamin D3 (D3) of 0.5 nM. In CV-1 cells, both RARα and RARα/VDR induce(More)
The chimeric receptor, RARalpha/VDR, contains the DNA-binding domain of the retinoic acid receptor (RARalpha) and the ligand-binding domain of the vitamin D receptor (VDR). The ligand-binding properties of RARalpha/VDR are equivalent to that of VDR, with an observed Kd for 1alpha,25 dihydroxy-vitamin D3 (D3) of 0.5 nM. In CV-1 cells, both RARalpha and(More)
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