S M Jancsár

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Bilateral ablation of the olfactory bulbs caused marked changes in the 'turnover' of several neurotransmitters in the amygdaloid cortex and the mid-brain areas of the rat brain. Following tyrosine and tryptophan hydroxylase inhibition, the decrease in the concentration of noradrenaline and serotonin respectively in the amygdaloid cortex was not so marked in(More)
The effects of (+/-)mianserin and its enantiomers on the behavioural hyperactivity of the olfactory bulbectomized (OB) rat and on the levels of some central neurotransmitters were investigated. The reversal of hyperactivity by racemic mianserin was found to be independent of dose within a non-sedative range of 2-10 mg/kg and occurred following seven days of(More)
Chronic treatment with a low dose of reserpine (0.1 mg/kg) caused rats to become hyperactive in the "open field" apparatus. When mianserin (5 mg/kg) or the selective serotonin uptake inhibitor ORG. 6582 (5 mg/kg) was chronically administered in combination with reserpine, the hyperactivity was attenuated. Both antidepressants were found to reverse the(More)
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