Learn More
BACKGROUND AND OBJECTIVES p53, c-erbB-2, and tumor microvascular density have been shown to be potential prognostic tools in female breast cancer. Our objective was to assess the significance of these biomarkers as prognostic factors in infiltrating male breast cancer. METHODS A retrospective study of expression of p53, c-erbB-2, and tumor microvascular(More)
BACKGROUND Genetic aberrations observed in the large bowel during the neoplastic progression have a cumulative effect and are responsible for the propagation of the multistep malignant process. In the present study we evaluated the immunoreactivity of c-fos, ras, bcl-2 and p53 in aberrant crypt foci (ACF) and minute polyps of the large bowel obtained from(More)
Ductal carcinoma in situ (DCIS) of the breast, a precursor lesion of invasive breast cancer, is a heterogeneous disease in terms of histomorphologic features and biologic behavior. Our aim was to assess the proliferative activity, expressed as topoisomerase IIalpha (Topo IIalpha) immunoreactivity and c-erbB-2 expression in relation to morphologic features(More)
A colchicine cuff was applied to rat sciatic nerve proximal to a demyelinating region produced by a focal injection of lysophosphatidylcholine (LPC). The colchicine cuff prevented the recovery of function normally seen within 6-8 days after LPC-induced demyelination. Colchicine blocked the delivery of sodium channels to the demyelinated region and induced(More)
Dieulafoy's lesion is an anomaly, difficult to diagnose, consisting of an abnormally dilated submucosal gastric blood vessel that can cause life-threatening gastric hemorrhage. Five patients with Dieulafoy's lesion and massive gastrointestinal bleeding are described. The diagnosis was made by endoscopy in two patients and during operation in the other(More)