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The central nervous dysfunctions of lethargy, fever and anorexia are manifestations of sepsis that seem to be mediated by increased cytokine production. Here we demonstrate that tumor necrosis factor (TNF)-alpha, an essential mediator of endotoxin-induced sepsis, prevents the proteasome-dependent degradation of RGS7, a regulator of G-protein signaling. The… (More)
BACKGROUND Studies have suggested that the incidence of classic Kaposi's sarcoma (KS) varies considerably within Europe. The epidemiology of classic KS in Denmark was described for the period between 1970 and 1992 and association with marital status and country of origin were evaluated. METHODS A descriptive epidemiology study was carried out using data… (More)
Prior to the 1980s, Kaposi's sarcoma was a rare tumour diagnosed three to four times more frequently among men than women. It was primarily seen among elderly men of Mediterranean or Jewish descent, in well-defined areas of Central Africa, or more scattered as individual cases with underlying immunosuppression. Geographical restrictions and suggested… (More)
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