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The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects for inter-subject analysis. In this context, knowledge of the regional cerebral blood flow (rCBF) distribution in normal ageing is a factor of the utmost importance. In the(More)
There is converging evidence of gray matter (GM) structural alterations in different limbic structures in Post-Traumatic Stress Disorder (PTSD) patients. The aim of this study was to evaluate GM density in PTSD in relation to trauma load, and to assess the GM differences between responders (R) and non-responders (NR) to EMDR therapy. Magnetic Resonance(More)
In a prospective randomized study we used erythrocyte scintigraphy to evaluate whether drainage reduced the hematoma volume after total hip arthroplasty. 12 patients were left without drains and 10 patients had two drains inserted, one below the fascia and one subcutaneously. We used tomographic registration (SPECT) to calculate the volume of the hematoma(More)
The influence of the positron distance of flight in various human tissues on the spatial resolution in positron emission tomography (PET) was assessed for positrons from carbon-11, nitrogen-13, oxygen-15, fluorine-18, gallium-68 and rubidium-82. The investigation was performed using the Monte Carlo code PENELOPE to simulate the transport of positrons within(More)
An integro-differential equation involving a convolution integral with a weakly singular kernel is considered. The kernel can be that of a fractional integral. The integro-differential equation is discretized using the discontinuous Galerkin method with piecewise constant basis functions. Sparse quadrature is introduced for the convolution term to overcome(More)
PURPOSE To compare advanced imaging techniques in the diagnosis of recurrent rectal cancer. MATERIAL AND METHODS Twenty-five consecutive patients with either suspected or verified recurrence were examined by CT (n = 25), MR with phased-array capabilities (n = 24) and CEA scintigraphy (n = 16). Three experienced radiologists (who were blinded to results(More)
[125I]- and [123I]NNC 13-8241 were prepared from the trimethyltin precursor and radioactive iodide using the chloramine-T method. The total radiochemical yields of [125I]- and [123I]NNC 13-8241 were 60-70% and 40-50% respectively, with radiochemical purity higher than 98%. In binding studies with [125I]NNC 13-8241 in rats in vitro and in vivo a high uptake(More)
Emission tomography provides three-dimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the image-degrading effects due to photon attenuation and scatter. Phantom experiments have shown(More)
OBJECTIVE It has been shown that [(18)F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can identify macrophage-rich high-risk atherosclerotic plaques in animal models as well as in patients with atherosclerotic plaques in the carotid arteries. The development of inflamed macrophage-rich plaques over time is not well known.(More)
The purpose of the study is to evaluate the combined accuracy of episodic memory performance and 18F-FDG PET in identifying patients with amnestic mild cognitive impairment (aMCI) converting to Alzheimer’s disease (AD), aMCI non-converters, and controls. Thirty-three patients with aMCI and 15 controls (CTR) were followed up for a mean of 21 months. Eleven(More)