• Citations Per Year
Learn More
PURPOSE This article evaluates how mathematical models of gas exchange, blood acid-base status, chemical respiratory drive, and muscle function can describe the respiratory response of spontaneously breathing patients to different levels of pressure support. METHODS The models were evaluated with data from 12 patients ventilated in pressure support(More)
This paper presents a mathematical model-approach to describe and quantify patient-response to changes in ventilator support. The approach accounts for changes in metabolism (V̇O2, V̇CO2) and serial dead space (VD), and integrates six physiological models of: pulmonary gas-exchange; acid-base chemistry of blood, and cerebrospinal fluid; chemoreflex(More)
Methods A set of mathematical models including pulmonary gas exchange, acid-base chemistry of blood and cerebrospinal fluid, blood oxygenation, O2 and CO2 transport and storage, ventilation, muscle function and chemoreflex respiratory drive were combined. The set of models was used to simulate changes in support during volume and pressure support(More)
Incomplete expiration of tidal volume can lead to dynamic hyperinflation and auto-PEEP. Methods are available for assessing these, but are not appropriate for patients with respiratory muscle activity, as occurs in pressure support. Information may exist in expiratory flow and carbon dioxide measurements, which, when taken together, may help characterize(More)
  • 1