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Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
- L. Muldoon, S. Walker-Rosenfeld, C. Hale, S. Purcell, L. Bennett, E. Neuwelt
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 2001
Modulation of glutathione has been proposed as a mechanism to alter the efficacy and toxicity of chemotherapeutic agents. We investigated in vitro cytoenhancement of chemotherapy toxicity by reducing… Expand
Trafficking of superparamagnetic iron oxide particles (Combidex) from brain to lymph nodes in the rat
- L. Muldoon, P. Várallyay, +4 authors E. Neuwelt
- Neuropathology and applied neurobiology
- 1 February 2004
Central nervous system (CNS) drainage may occur via connections to the vasculature, but in animal models up to 50% occurs via perivascular, perineural and primitive lymphatic drainage to cervical… Expand
Effect of Antigenic Heterogeneity on the Efficacy of Enhanced Delivery of Antibody-targeted Chemotherapy in a Human Lung Cancer Intracerebral Xenograft Model in Rats
- E. Neuwelt, L. Thrun, S. Walker-Rosenfeld, Andrew T. Cave, L. Muldoon
- 1 December 2003
OBJECTIVEThe SGN-15 monoclonal antibody-doxorubicin immunoconjugate is toxic to LewisY antigen-expressing cells and is effective against intracerebral tumors in nude rats when delivery is enhanced… Expand