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Recombinant adeno-associated virus vectors (AAV) were prepared in high titer (10(12) to 10(13) particles/mL) for the expression of human factor IX after in vivo transduction of murine hepatocytes. Injection of AAV-CMV-F.IX (expression from the human cytomegalovirus IE enhancer/promoter) into the portal vein of adult mice resulted in no detectable human(More)
We sought to determine whether intramuscular injection of a recombinant adeno-associated virus (rAAV) vector expressing human factor IX (hF.IX) could direct expression of therapeutic levels of the transgene in experimental animals. High titer (10(12)-10(13) vector genomes/ml) rAAV expressing hF.IX was prepared, purified, and injected into hindlimb muscles(More)
Mice with hemophilia B have been engineered using gene targeting techniques. These animals exhibit severe factor IX deficiency and a clinical phenotype that mirrors the human disease. We have bred the founder animals onto two different strains of mice, C57B1/6 and CD-1, and have sought to determine whether adenoviral vectors expressing human factor IX could(More)
Bandit problems provide an interesting and widely-used setting for the study of sequential decision-making. In their most basic form, bandit problems require people to choose repeatedly between a small number of alternatives, each of which has an unknown rate of providing reward. We investigate restless bandit problems, where the distributions of reward(More)
The phenomenon of the ‘wisdom of the crowds’ refers to the finding that the aggregate of a set of proposed solutions from a group of individuals performs better than the majority of individual solutions. We investigated this effect in the context of planar Euclidean traveling salesperson problem (TSP). The goal in TSPs is to estimate the shortest tour(More)
In this paper, we propose a 3D HMM (Three-dimensional Hidden Markov Models) approach to recognizing human facial expressions and associated emotions. Human emotion is usually classified by psychologists into six categories: Happiness, Sadness, Anger, Fear, Disgust and Surprise. Further, psychologists categorize facial movements based on the muscles that(More)
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