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OBJECTIVE Balanitis xerotica obliterans (BXO) is a chronic inflammatory disease that is considered as male genital variant lichen sclerosis. The incidence varies greatly in different series; diagnosis is mostly clinical but histopathological confirmation is mandatory. Various treatments are described, but there is no consensus that one is the best. … (More)
Sparing sensitive healthy tissue from chemotherapy exposure is a critical challenge in the treatment of cancer. The work described here demonstrates the localized in vivo photoactivation of a new chemotherapy prodrug of doxorubicin (DOX). The DOX prodrug (DOX-PCB) was 200 times less toxic than DOX and was designed to release pure DOX when exposed to 365 nm… (More)
We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. pneumoniae outbreak in a 20-bed surgical intensive care unit during the period from January 1, 2009 through January 1, 2010. Nine patients were either colonized or infected with a monoclonal strain of K. pneumoniae. The implementation of a bundle of interventions… (More)
Extensive field methodology has been developed for the sampling of sediment conditions, channel geometry, and aquatic insect populations in wadable rivers. This presentation will expand on the question: What happens when the water is a bit too deep to wade, yet too shallow and swift for boat-based methods? Additionally, we will investigate how commonly… (More)
Commercially available UV powder was applied weekly to high-risk objects within patient rooms and inspected after 48 hours. We found a baseline cleaning rate of 41.8% that increased up to 80% (P < .001) after the institution of weekly electronic feedback (unit rates and rankings) to environmental services, hospital leadership, and unit administrators.
The localized conversion of inactive doxorubicin prodrug chemotherapeutics to pharmacalogically active forms is difficult to quantify in mouse tumor models because it occurs only in small regions of tissue. The tumor tissue extraction protocol and LC-MS/MS analysis method described here were optimized to obtain a detection limit of 7.8 pg for the activated… (More)