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The basal ganglia (BG) are involved in gait. This notion is exemplified by observations that gait is disturbed by most diseases that affect the BG. However, it is unclear in what way the BG are activated during gait. One method to investigate the activity of the BG is to record local field potentials (LFPs) from electrodes placed in the BG for therapeutic(More)
BACKGROUNDS Deep brain stimulation is widely used for the treatment of movement disorders such as Parkinson's disease and dystonia. After the implantation of electrodes an immediate improvement of clinical symptoms has been described. It is unclear, whether movement kinematics are also changed by this 'microlesion effect'. METHODS To gain further insight(More)
Physical examination, interviews with patients and the results of rating scales for movement disturbances are the basis for the assessment of Parkinson's disease (PD). However, subjectivity in the assessment of the symptoms and the short period of observation are disadvantageous. This paper presents the results of a study to assess the feasibility of using(More)
Deep brain stimulation of the internal globus pallidus (GPi) is a major treatment for advanced Parkinson's disease. The effects of this intervention on electrical activity patterns in targets of GPi output, specifically in the thalamus, are poorly understood. The experiments described here examined these effects using electrophysiological recordings in two(More)
OBJECTIVE Loud acoustic stimuli at 500Hz activate the vestibular system. Intermediate-latency vestibular cortical potentials of multimodal cortex regions were investigated, beyond the 20ms time range. METHODS Eighteen healthy subjects with 32-channel EEG and one epilepsy patient with right-sided intracortical electrodes received three types of stimuli:(More)
Vestibulospinal reflexes are important for upright stance and locomotor control. Information from both the vestibular and the proprioceptive system must be combined centrally to guarantee appropriate compensation for a physical disturbance. Recent single-unit recordings from the monkey demonstrated vestibulo-proprioceptive interaction in the fastigial(More)
Cerebellar dysfunction results in ataxia including postural deficits. Evidence from animal experiments suggests convergence of vestibular and neck-position related inputs in cerebellar midline structures. We investigated 20 ambulatory patients with cerebellar disease for disturbed postural control using posturography during static lateral head turns.(More)
Conventional anti-Parkinsonian dopamine replacement therapy is often complicated by side effects that limit the use of these medications. There is a continuing need to develop nondopaminergic approaches to treat Parkinsonism. One such approach is to use medications that normalize dopamine depletion-related firing abnormalities in the basal(More)
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