S. K. Tolani

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Leukocytosis is associated with increased cardiovascular disease risk in humans and develops in hypercholesterolemic atherosclerotic animal models. Leukocytosis is associated with the proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux-promoting ABC transporters ABCA1 and ABCG1(More)
OBJECTIVE We previously demonstrated that subjects with functional ATP-binding cassette (ABC) A1 mutations have increased atherosclerosis, which has been attributed to the role of ABCA1 in reverse cholesterol transport. More recently, a proinflammatory effect of Abca1 deficiency was shown in mice, potentially contributing to atherogenesis. In this study, we(More)
H igh-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with cardiovascular risk. The ath-eroprotective effects of HDL have traditionally been attributed to its role in reverse cholesterol transport. The ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in mediating cholesterol efflux from peripheral cells, including(More)
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