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It has been long suspected that the increased work required to move the ponderous thoracic wall and abdomen during breathing was responsible for hypoventilation and retention of carbon dioxide in the obesity-hypoventilation or "Pickwickian" syndrome (1-4). Increased oxygen cost of ventilation, decreased lung compliance, increased pressure-volume work done(More)
PURPOSE Melatonin has neuroprotective effects in animal studies and has been suggested to decrease adverse reactions of chemotherapy including neuropathy. This pilot trial aimed at assessing whether melatonin, given during taxane chemotherapy for breast cancer, will decrease the incidence and/or severity of neuropathy. METHODS Twenty two consecutive(More)