S K Sharpless

Learn More
The are numerous supersensitivity-like changes in the central nervous system associated with denervation and disuse. There is little evidence, however, for increases in postjunctional sensitivity exactly parallel to that which occurs in disused effector organs. As we learn more about the mechanisms responsible for supersensitivity in effector organs, it(More)
The use of chronic intravenous cannulae implanted in the jugular vein of mice utilizing techniques previously developed for larger rodents is discussed. Two cannula designs and a chronic infusion chamber are illustrated. Cannula insertion depths for mice of three strains and various body weights, and estimates of operative mortality and cannula durability(More)
This paper suggests that compression block in nerve can be better interpreted in terms of a pressure vessel model for nerve fiber distension that the more common models based upon tubes with more or less rigid walls. In this model resistance to compression is due to the elasticity of the cell membrane at locations where displaced intracellular fluid tends(More)
Mice of the C57BL/6J strain can be made susceptible to audiogenic seizures by a process known as acoustic priming. Acoustic priming can be blocked when the animals are injected either with puromycin or with puromycin aminonucleoside before the application of the priming stimulus. Cycloheximide, diphenylhydantoin, and d-amphetamine had little effect on(More)
Cortical electroencephalographic (EEG) changes induced by ethanol (4.3 and 1.4 g/kg, ip), pentobarbital (50 and 16 mg/kg), and nicotine (1.0 g/kg) were examined in long-sleep (LS) and short-sleep (SS) mice that were genetically selected for differential sleep times induced by a hypnotic dosage of ethanol. Ethanol (4.3 g/kg) caused EEG changes that(More)
The long-sleep (LS) and short-sleep (SS) lines of mice were derived by selective breeding with respect to ethanol sleep time. We found that in current generations LS mice also have longer sleep times than SS mice to trichloroethanol and paraldehyde. Two subsequent experiments tested our hypothesis that mice that are relatively insensitive to the hypnotic(More)
  • 1