- Full text PDF available (0)
- This year (0)
- Last five years (0)
Dimebone was shown to inhibit monoamine oxidase (MAO) deaminating dopamine and serotonin, decrease dopamine metabolism in the basal ganglia of the rat brain, increase noradrenaline level and depress dopamine deamination in the hypothalamus. Dimebone first increased and then diminished the release of dopamine in the cortex, with the concomitant MAO… (More)
In the experiment on rats it was shown that injection of somatotropin (1 ED/kg, i.m. at 1, 3, 5, 7 and 9 days) after combined irradiation and mechanical injury (4.5 Gy, LD50/30 and plural fractures) improved the overall condition of the rats and increased the survival. The drug accelerated the bone regeneration.
It was reported previously that the analogues of dimecabin (1,2-dimethyl-3-carbethoxy-5-oxyindole),2-methyl-3-carbethoxy-5-oxyindole and the derivatives of 2-methyl-3-carbethoxy-4, 5, 6, 7-tetrahydroindole substituted in the 1st position reduce the content of argentaffinic substance in enterochromaffin cells (EC) for a long period of time. It has been shown… (More)