S-K Poon

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The erythromycin breath test (EBT) is a standard test used to evaluate the extent of CYP3A4 activity. This study examines whether presumed changes in CYP3A4 activity are in fact related to inhibition of an uptake organic anion transporter using rifampin and inhibition of the efflux hepatic P-glycoprotein transporter using lansoprazole. Three EBT tests in(More)
Awake Sprague-Dawley rats were depleted of brain serotonin (5HT) by intraventricular injections of 50 micrograms 5,7-dihydroxytryptamine (5,7-DHT) through chronically implanted cannulae. Oral pretreatment with 25 mg/kg desmethylimipramine was used to protect brain noradrenergic neurons from 5,7-DHT. In a separate set of animals, liquid chromatographic(More)
BACKGROUND AND STUDY AIMS Rebleeding can occur after endoscopic injection of gastric varices with tissue adhesive. The aim of this study was to evaluate whether adjuvant hypertonic glucose solution injections enhance the effects of Histoacryl after successful initial variceal obliteration. PATIENTS AND METHODS A total of 67 patients (37 men, 30 women;(More)
Immediately following a double-toe transfer to her hand, a 40-year-old woman developed a severe migraine headache unrelieved by narcotics. Medical consultation was obtained, and available medical treatments were discussed in relation to their possible effects on the patient's recent microvascular procedure. Intravenous steroids were administered, with(More)
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