S. K. Chadha

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In a study of 530 individuals with non-syndromic, sensorineural hearing loss, we identified 18 mutations at connexin 26 (Cx26), four of which are novel (-23G>T, I33T, 377_383dupTCCGCAT, W172R) and the remaining 14 (ivs1+1G>A, M1V, 35delG, W24X, I35S, V37I, R75W, W77X, 312del14, E120del, Q124X, Y136X, R143W, R184P) being mutations previously described. To(More)
Larynx is responsible for the generation of voice and subsequently impacts on communication, social interaction, personality, and artistic expression. The vocal instrument is comprised of the vibratory body, the respiratory power source, and the oropharyngeal resonating chamber. The lungs are the power supply, the larynx is the vibratory source, and the(More)
Mutations in the autosomal genes TMPRSS3, TMC1, USHIC, CDH23 and TMIE are known to cause hereditary hearing loss. To study the contribution of these genes to autosomal recessive, non-syndromic hearing loss (ARNSHL) in India, we examined 374 families with the disorder to identify potential mutations. We found four mutations in TMPRSS3, eight in TMC1, ten in(More)
OBJECTIVE This study aimed to assess the prevalence and profile of ear diseases in children from Delhi, India. METHODS A population-based cross-sectional door-to-door survey was carried out in two districts of Delhi, and involved children of all demographic sections of the region. A total of 4626 children aged between 18 days and 15 years underwent(More)
BACKGROUND There is a considerable scarcity of reliable population-based data on the prevalence of preventable ear disorders in developing countries. This study was conducted to determine the prevalence of preventable ear disorders in primary school children (aged 5 to 12 years) in northern India. METHOD A pro forma questionnaire was used to screen 15 718(More)
The high burden of deafness globally and in India is largely preventable and avoidable. According to the 2005 estimates of WHO, 278 million people have disabling hearing impairment. The prevalence of deafness in Southeast Asia ranges from 4.6% to 8.8%. In India, 63 million people (6.3%) suffer from significant auditory loss. Nationwide disability surveys(More)
This study was conducted with an aim to assess the prevalence and profile of ear diseases in children from the higher and lower socioeconomic strata of society. Two groups of schools within Delhi were selected. Group A comprised of government schools located in slum areas with an average parental income of INR (Indian National Rupees) 1050 per month and(More)
Around 7% of the population of India suffers from profound deafness. More than a million children needs either hearing aid or cochlear implant surgery to restore their hearing power. Many of them had never heard a single word since their birth. Still only 5000 cochlear implant surgery has been conducted in the country, the first being nearly 20 years ago,(More)
UNLABELLED Philanthropy continues to play an important role in provision of hearing devices and is often the only alternative for the majority of those in need of these devices. While this leads to improved access to services it may also create unsustainable service delivery models. Over the past decade, World Health Organization (WHO) has been making(More)
This study aims to compare the various audiological tests that are currently available as screening tools for infant hearing assessment. In developing countries, which have limited resources, it is imperative to design a screening programme that is easy to perform, gives accurate results, has good patient acceptability and is cost effective. Fifty infants,(More)