Antibodies that immunoprecipitate (125)I-alpha-dendrotoxin-labelled voltage-gated potassium channels extracted from mammalian brain tissue have been identified in patients with neuromyotonia, Morvan's syndrome, limbic encephalitis and a few cases of adult-onset epilepsy. These conditions often improve following immunomodulatory therapies. However, the… (More)
IMPORTANCE High titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA), and impaired function of GABAergic neurons has been implicated in the pathogenesis of SPS. Autoantibodies to… (More)
BACKGROUND Corticobasal degeneration (CBD) is a complex neurodegenerative disorder. Accurate diagnosis is increasingly important, with the advent of clinical trials of drugs aimed at modifying the underlying tau pathology. CBD often presents with a 'corticobasal syndrome' including impairments of movement and cognition. However, patients with similar… (More)
In nano-medicine, mesoporous silicon particles provide efficient vehicles for the dissemination and delivery of key proteins at the micron scale. We propose a new quality-control method for the nanopore structure of these particles, based on image analysis software developed to automatically inspect scanning electronic microscopy (SEM) images of… (More)
The behavioural variant of frontotemporal dementia (bvFTD) is characterised by personality change with a decline in cognition. We describe two patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukencephalopathy (CADASIL) who presented with behavioural phenotypes similar to bvFTD. The first patient presented with… (More)
We report an unusual case of bilateral mirror-image arteriovenous malformations (AVMs) in association with a large internal carotid aneurysm. The patient, a 45-year-old man, was asymptomatic apart from a lump in his neck. Both AVMs were successfully occluded with embolisation and the patient remains clinically well.