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BACKGROUND Deteriorating cognitive function in late life substantially increases the risk for dementia, for other non-cognitive morbidity, for dependency, and early death. AIMS To identify early predictors of late-life cognitive outcome. METHOD Cognitive function, premorbid IQ, and cardiovascular risk exposure were recorded on 1083 subjects on entry to(More)
OBJECTIVE The effect of APOE on dementia may be mediated through dyslipidemia and atherogenesis through its effect on cholesterol metabolism. The authors investigated this possibility among aged survivors from the UK Medical Research Council Trial of the Treatment of Hypertension in Older Adults. DESIGN A total of 370 of 657 survivors from an initial(More)
OBJECTIVE To determine whether a cognitive test package can predict the onset of dementia up to 11 years later, and the extent to which this prediction is independent of that provided by APOE genotype. METHODS Prospective cohort study based on 54 general practices in the UK; 657 survivors of the 1088 participants in the MRC treatment trial of hypertension(More)
BACKGROUND Previous longitudinal studies of the association between depression and cognitive dysfunction have had relatively short follow-up periods. This report presents a long-term study of the association between baseline syndromal depression and cognitive outcome measured 9 to 12 years later. METHODS Self-CARE (D) depression, cognitive function and(More)
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