S. Jeffress Williams

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The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human(More)
OBJECTIVE To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women. METHODS A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson(More)
The medium chain triglyceride ketogenic diet is an established treatment for drug-resistant epilepsy that increases plasma levels of decanoic acid and ketones. Recently, decanoic acid has been shown to provide seizure control in vivo, yet its mechanism of action remains unclear. Here we show that decanoic acid, but not the ketones β-hydroxybutryate or(More)
BACKGROUND HIV-infected women are at increased risk for developing cervical cancer. Women living in resource-limited countries are especially at risk due to poor access to cervical cancer screening and treatment. We evaluated three cervical cancer screening methods to detect cervical intraepithelial neoplasia grade 2 and above (CIN 2+) in HIV-infected women(More)
With continuing influx of large numbers of people into coastal regions, human stresses on coastal ecosystems and resources are growing at the same time that climate variability and change and associated consequences in the marine environment are making coastal areas less secure for human habitation. The article reviews both climatic and nonclimatic drivers(More)
International agreements and policies play an increasingly prominent role in strategies to combat biodiversity loss. However, conservation policies can only have a conservation impact if implemented. Identifying factors determining the influence of a policy on institutions could improve the process of policy development and communication. We examine how and(More)
Who Harvests and Why? Characteristics of Guatemalan Households Harvesting Xaté (Chamaedorea ernesti-augusti). Cultivation of harvested species is frequently proposed as a conservation strategy to reduce wild harvesting pressure and improve local livelihoods. The success of this approach is likely to be influenced by harvesters’ socioeconomic(More)
BACKGROUND The risk of squamous intra-epithelial lesions (SIL) is higher in HIV-positive women. As these women begin to live longer due to highly active antiretroviral therapy (HAART), their risk of cervical cancer may increase. Few data exist regarding the effect of HAART on the incidence and progression of SIL in HIV-positive African women. The aim of(More)
OBJECTIVE South Africa has very high rates of both HIV infection and cervical pathology. The management of ASC-H is colposcopy and directed biopsy, but with so many women diagnosed with HSIL and a dearth of colposcopy centres in South Africa, women with cytologic diagnosis of ASC-H may not be prioritized for colposcopy. The aim of this study was to(More)
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