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Miniature osmotic delivery systems were constructed and tested in various environments according to the design criteria described in the present paper. These devices, when activated by water, can deliver a variety of solutions or suspensions at zero-order rates for periods of hours up to several weeks. The osmotic pumps consist of a cylindrical reservoir(More)
Evaluation and selection of drugs, and determination of the optimal regimen, for controlled-release pharmaceutical products necessitate the reassessment of the pharmacology of drugs delivered at controlled rates. We have developed osmotic pumps for this purpose. These pumps, 1- and 2-week duration implants for animal studies, and 12- and 24-hour forms for(More)
New and emerging capillary blood sampling technologies for self-monitoring of blood glucose (SMBG) are reviewed for their impact on factors pertaining to users such as pain, and from the standpoint of skin physiology and technical feasibility. Innovative blood sampling techniques based on lancets for skin penetration on nonfinger (alternate) sites such as(More)
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) exhibit potency for the regeneration of infarcted hearts. Vascular endothelial growth factor (VEGF) is capable of inducing angiogenesis and can boost stem cell-based therapeutic effects. However, high levels of VEGF can cause abnormal blood vessel growth and hemangiomas. Thus, a(More)
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