S. I. Woods

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When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is supported by indirect evidence showing that multi-copy genes show loss-of-function phenotypes less often than single-copy genes and by direct tests of(More)
Family and twin studies indicate that melanoma susceptibility has a strong genetic component. Very rarely, mel-anoma runs in families in which there is an inherited mutation in a single 'high penetrance' gene, but in the general population melanoma susceptibility is thought to be governed by variation in a series of 'low pene-trance' genes. We sought to(More)
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