S I Sushel'nitskiĭ

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The influence of the epidermal growth factor (EGF, 5 ng/ml) and(or) insulin (1 microgram/ml) on the number of transforming growth factor beta (TGF-beta) specific binding sites in cells with different proliferative response on the TGF-beta action and on the affinity (Kd) of these sites to the ligand was studied. The total amount of TGF-beta binding sites(More)
Cells of line CHO-719 from the Chinese hamster ovary have no epidermal growth factor receptors. It was detected that these cells were significantly stimulated to proliferate in a semisolid culture medium containing 0.33% agar by transforming growth factor beta (TGF-beta) in combination with insulin. This effect was even more pronounced when the cells of(More)
The influence of different concentrations of a transforming growth factor of type beta (TGF-beta) and of its combinations with the epidermal growth factor (EGF) and insulin exerted on proliferation of different types of cells in the culture medium with semisolid agar was determined. The following cell lines were tested: mouse fibroblasts of NIH-3T3 and(More)
A study was made of the influence of transforming growth factor beta (0.05-50.00 ng/ml) on the intensity of 3H-thymidine incorporation in the DNAs of pseudonormal mouse fibroblasts of NIH 3T3 line, of cells of NRK-49F line from normal rat kidney, and of cells of A-549 line from human lung adenocarcinoma. The experiments were carried out in the absence and(More)
It was shown previously that cells of sarcoma PS-103 induced in mouse by subcutaneous transplantation of plastic film produce growth-stimulating activity. In this communication clone 3 sb, isolated from sarcoma PS-103, was studied. Growth factor produced by the cells of this clone stimulated proliferation of quasi-normal (3T3, NRK) cells and transformed(More)
The influence of serum-free media, previously conditioned by A-549 line cells of the human lung adenocarcinoma (c-medium), on the intensity of 3H-thymidine incorporation into DNA of the same cells was studied. It was found that, depending on the duration of conditioning (2, 4 and 6 days), the c-media were obtained with corresponding values of pH--7.2, 6.9(More)
Substances which (depending on their dose) stimulate [3H]thymidine incorporation into the trichloracetic acid insoluble fraction of the in vitro cultured mouse NIH-3T3 cells were isolated from the blastoderm and from the yolk of the teleost fish loach embryos (8-9 hours after the eggs' fertilization) by the acid-ethanol extraction method. In the medium(More)
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