S. I. Golovko

  • Citations Per Year
Learn More
Naltrexone and naloxone, being competitive antagonists of opioid receptors, have found therapeutic applications in medicine. The experiments with mutant receptors showed that many amino acid residues within transmembrane domains play an important role in binding these drugs. Using the site-directed mutagenesis technique, it was established that even single(More)
The properties of acamprosate (calcium acetylhomotaurate), a new remedy for the treatment of alcoholism, are reviewed. The efficacy of this drug has been verified by numerous clinical tests in West Europe. The pharmacological activity of acamprosate is related to the drug action upon central neuromediator systems. No side or addiction effects of the drug(More)
Morphometrical parameters, osmoregulatory possibilities, and the value of membrane reserve of nucleated hemocytes (leukocytes and erythrocytes) of the main vertebrate animal classes were studied with use of the method of hypoosmotic loadings. It has been established that in erythrocytes, in the fish—mammal row, the absolute reserve of plasmalemma increases,(More)
Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABAA, GABAB, and GABAC receptors. GABAA is the most abundant type of GABA receptors. It consists of six classes of subunits, α, β, γ, δ, ε, and χ. Acute and chronic exposures to ethanol are accompanied by changes in structure(More)
Syndrome of psychic dependence on psychoactive substances (craving) is a substantial part of chemical addictive disorders (drug addiction and alcoholism). Theories of addiction (alcoholism) have mainly been developed from neurobiology, neurochemistry, physiology, psychology. In the last years a large number of studies were conducted on the effect of(More)
Ultra rapid opioid detoxification (UROD) is a new technique with the use of mu-opioid receptor antagonists to precipitate withdrawal. The scientific literature on UROD techniques in opiate addicts are reviewed, but little has been published on its neurochemical aspects. It is discussed that exposure to naloxone ore naltrexone during UROD is associated with(More)
The authors present a comparative analysis of long-term results of transcutaneous urethrocystocervicopexy (TU) with a vaginal graft according to O. B. Loran-D. Yu. Pushkar and its modification. The former method provided good 2-year results in correction of urinary stress incontinence (USI) in 84.8% of cases, satisfactory and unsatisfactory results were(More)