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A carcinoembryonic antigen(CEA)-produclng humanlungcancercell line (A549), a nonprodudng human lung cancer cell line (CADO-LC9), and a humanuterinecervicalcancer(HeLa)were transfectedwith the herpes simplex virus thymidine kinase (HSV.TK) gene regulated by 445 nucleotides upstream from the translational start of CEA gene. Fifty % growth inhibitory(More)
Photodynamic therapy (PDT) in early squamous cell carcinoma of the bronchus has been shown to result in complete response (CR) and cure. However, local recurrence after PDT develops frequently even after complete remission. Because the effect of PDT had been reported to depend on apoptosis, and apoptosis is inhibited by bcl-2 protein, the relationship(More)
To evaluate the efficacy and toxicity of the sequential nonplatinum combination chemotherapy consisting of gemcitabine (GEM) and vinorelbine (VNR) followed by docetaxel (DOC) in patients with advanced non-small-cell lung cancer (NSCLC), we conducted the multiinstitutional phase II study. A total of 44 chemotherapy-naive patients with advanced NSCLC were(More)
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