S Hashimoto-Kitsukawa

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1. The ability of VA-045 to improve aged-related impairment on electroencephalograph (EEG), caudate spindle, performance on a passive avoidance task and cerebral blood flow (CBF) were evaluated in rats. 2. The cortical EEG of the aged rats showed a higher incidence of spontaneous spindle burst (SSB) than seen in young rats. VA-045 decreased the incidence of(More)
We studied the effects of taurine on the caudate spindle in rats and compared the findings with those of gamma-aminobutyric acid (GABA) when these compounds were microinjected into the bilateral striatum. Three micrograms of taurine was without effect, whereas 10 and 30 micrograms of taurine enhanced the spindle in a dose-dependent manner. GABA (3-100(More)
Bilateral injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle of rats resulted in destruction of dopamine (DA) nerve terminals in the striatum. DA contents decreased to 16.8, 15.0 and 13.7% of control values on 3, 5 and 7 days after the lesions, respectively. The time course of the effect of 6-OHDA lesions on apomorphine (0.5 mg/kg,(More)
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