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It has long been known that emotionally arousing events are more likely to be later recollected than similar, neutral events2. An extreme example of this enhancement of memory by emotion is the so-called flashbulb memory: a highly vivid memory for an intensely emotionally engaging event such as hearing the news of the death of a relative or cherished(More)
puts you in pleasant spirits as the day begins. But as you open the milk to pour into the coffee, your nose suddenly wrinkles at its spoiled smell, and your mood a different emotion-related region, the orbitofrontal cortex, responded almost exclusively to the pleasantness or unpleasantness of the odors. This fascinating glimpse into how the brain organizes(More)
Thyroid hormone (T3) is essential for normal development, differentiation and metabolic balance. We have performed DNA microarray experiments using hepatic RNA from hypothyroid and T3-treated hypothyroid rats in order to characterize T3-induced gene expression patterns after various time points (6, 24 and 48 h after the administration of the hormone).(More)
Detection of somatic low abundance mutations in early cancer development requires a discriminatory, specific, and high-throughput methodology. In this study we report specific, discriminatory detection of low abundance mutations through a novel combination of rolling circle amplification (Nat Genet 1998; 19:225-232) and PCR ligation detection reaction on a(More)
The detection of specific RNA molecules in situ is routinely performed using haptenated probes, which are detected by either enzymatic amplification or direct fluorescence. A drawback of fluorescence labeling has been the reduced sensitivity relative to that of methods that use enzymes as signal generators. Reliable fluorescence detection methods often(More)
The considerably higher power and wider frequency coverage available from quantum cascade lasers (QCLs) in comparison to lead salt diode lasers has led to substantial advances when QCLs are used in pure and applied infrared spectroscopy. Furthermore, they can be used in both pulsed and continuous wave (cw) operation, opening up new possibilities in(More)
S1 Identifying and assessing women at high risk for breast cancer JE Garber Dana Farber Cancer Institute, Boston, MA, USA Breast Cancer Research 2009, 11(Suppl 1):S1 (doi: 10.1186/bcr2262) There has been progress in the identification of factors that confer important risk for the development of breast cancer. The factors include: heritable mutations in(More)